![]() ![]() Testing and have potential reaction mechanism(s) implicated. Their allergy evaluated without specialist intervention, and high-risk patients would be referred for allergy diagnostic Ideally, patients at low risk for allergy would have ![]() Despite these threats, the histories associated with documentedĪllergies are rarely reconciled, or acted on, by the health care team. Inaccurately determined allergies might result in the use of unnecessarily broad-spectrum or inferiorĪntibiotics, posing a threat to patient safety and public health. Of penicillin allergy, this Review provides a global update on antibiotic allergy epidemiology, classification, mechanisms, andĪntibiotics can result in adverse drug reactions (ADRs) and hypersensitivity reactions (HSRs) through a variety of mechanisms.Īntibiotic allergies are frequently documented in the electronic health record, which results in changes to the care of future Penicillins are not allergic when appropriately stratified for risk, tested, and re-challenged. A penicillin allergy label, in particular, is associated with increased use of broad-spectrum and non-β-lactamĪntibiotics, which results in increased adverse events and antibiotic resistance. Antibiotic allergy labels result in displacement of first-line therapies for antibiotic prophylaxis and Although such reactions pose negligible risk to patients, they currently represent a global However, many antibiotic reactions documented asĪllergies were unknown or not remembered by the patient, cutaneous reactions unrelated to drug hypersensitivity, drug-infection Including anaphylaxis, and organ-specific and severe cutaneous adverse reactions. Antibiotics are the commonest cause of life-threatening immune-mediated drug reactions that are considered off-target, ![]()
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